منابع مشابه
Building centrioles
he protozoan parasite Toxoplasma gondii heads out of its host cell when Ca 2 ϩ levels peak in its cytoplasm. Now, Arrizabalaga et al. (page 653) find that proper regulation of these Ca 2 ϩ levels, and thus of Toxoplasma exit, requires a Na ϩ /H ϩ exchanger (NHE), suggesting a link between proton and Ca 2 ϩ regulation. The increase in Ca 2 ϩ levels, which can be induced artificially with an iono...
متن کاملCentrioles take center stage
Centrioles are among the most beautiful and mysterious of all cell organelles. Although the ultrastructure of centrioles has been studied in great detail ever since the advent of electron microscopy, these studies raised as many questions as they answered, and for a long time both the function and mode of duplication of centrioles remained controversial. It is now clear that centrioles play an ...
متن کاملBirth control for centrioles
You wouldn't call it a long-term relationship, but the interaction between proteins and certain membrane lipids is not just a one-millisecond stand. As Hammond et al. discovered, the proteins remain attached to the lipids longer than researchers expected. The fi ndings explain how these lipids localize their effects. By temporarily hooking up with various proteins, inositol lipids in the plasma...
متن کاملBirth control for centrioles
In This Issue In This Issue Birth control for centrioles mnis centriolus e centriolo—every centriole comes from a centriole. This statement underlies the standard model of centrosome duplication, in which daughter centrioles that will form the foundation of a new centrosome must be patterned on some kind of template provided by a mother centriole. On page 1171, Khodjakov et al. now demonstrate ...
متن کاملCentrioles: Duplicating Precariously
To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-existing centrioles challenges the idea th...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2015
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/20153103008